NSC 48160 suppresses the growth of pancreatic cancer cells with IC50 of 84.3 μM for CPFAC-1 and IC50 of 94.5 μM for BxPC-3. NSC 48160 can also cause apoptosis in pancreatic cancer cells. NSC 48160 can improve metabolic syndromes such as NASH, obesity and lipid metabolism disorders.

Physicochemical Properties

Molecular Formula	C18H29NO
Molecular Weight	275.43
Exact Mass	275.225
CAS #	6640-90-0
PubChem CID	241059
Appearance	Typically exists as solid at room temperature
Density	1g/cm3
Boiling Point	387.3ºC at 760 mmHg
Flash Point	67.2ºC
Index of Refraction	1.538
LogP	4.811
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	2
Rotatable Bond Count	4
Heavy Atom Count	20
Complexity	290
Defined Atom Stereocenter Count	0
SMILES	CC1=CC(=CC(=C1O)CNC2CCCCC2)C(C)(C)C
InChi Key	DVMJYVSFWOSELO-UHFFFAOYSA-N
InChi Code	InChI=1S/C18H29NO/c1-13-10-15(18(2,3)4)11-14(17(13)20)12-19-16-8-6-5-7-9-16/h10-11,16,19-20H,5-9,12H2,1-4H3
Chemical Name	4-tert-butyl-2-[(cyclohexylamino)methyl]-6-methylphenol
HS Tariff Code	2934.99.9001
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment (e.g. under nitrogen), avoid exposure to moisture and light.
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

References

[1]. Li D, et al. A small-molecule induces apoptosis and suppresses metastasis in pancreatic cancer cells. Eur J Pharm Sci. 2013 Mar 12;48(4-5):658-67. [2]. Liu zuijia, et al. Application of small molecule compound NSC48160 in preparation of medicine for treating non-alcoholic fatty liver disease. Patent. CN115869292

Solubility Data

Solubility (In Vitro)

DMSO : ~100 mg/mL (~363.07 mM)

Solubility (In Vivo)

Solubility in Formulation 1: ≥ 2.5 mg/mL (9.08 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (9.08 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly.  (Please use freshly prepared in vivo formulations for optimal results.)

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	3.6307 mL	18.1534 mL	36.3069 mL
	5 mM	0.7261 mL	3.6307 mL	7.2614 mL
	10 mM	0.3631 mL	1.8153 mL	3.6307 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.