NNISC-2 (compound 4) is a DNA intercalator-linker conjugate of Naph-Se-TMZ, which is composed of DNA intercalator (blue part) Nitro-Naphthalimide-C2-acylamide and molecular linker (black part).

Physicochemical Properties

Molecular Formula	C15H9N3O4SE
Molecular Weight	374.21
CAS #	2097636-47-8
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

Targets	Cereblon
References	[1]. Synthesis and characterization of a novel Naphthalimide-Selenium based Temozolomide drug conjugate in glioma cells. Bioorg Chem. 2024 Nov 26;154:107998.

Solubility Data

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	2.6723 mL	13.3615 mL	26.7230 mL
	5 mM	0.5345 mL	2.6723 mL	5.3446 mL
	10 mM	0.2672 mL	1.3361 mL	2.6723 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.