NAMI-A is a ruthenium-based agent characterized by selective activity against tumor metastasis, inhibiting adhesion and migration.

Physicochemical Properties

Molecular Formula	C8H15CL4N4ORUS
Molecular Weight	458.177895784378
Exact Mass	458.873
CAS #	201653-76-1
PubChem CID	133082692
Appearance	Pink to red solid powder
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	7
Rotatable Bond Count	0
Heavy Atom Count	19
Complexity	81.2
Defined Atom Stereocenter Count	0
SMILES	[Ru+3].[Cl-].[Cl-].[Cl-].[Cl-].S(C)(C)=O.[NH+]1C=CNC=1.N1C=NC=C1
InChi Key	RJZBTXZRLXLLKO-UHFFFAOYSA-K
InChi Code	InChI=1S/2C3H4N2.C2H6OS.4ClH.Ru/c2*1-2-5-3-4-1;1-4(2)3;;;;;/h2*1-3H,(H,4,5);1-2H3;4*1H;/q;;;;;;;+3/p-3
Chemical Name	1H-imidazole;1H-imidazol-3-ium;methylsulfinylmethane;ruthenium(3+);tetrachloride
Synonyms	ImH-trans-RuCl4(DMSO)-Im; NAMIA
HS Tariff Code	2934.99.9001
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

References

[1]. Dual Action of NAMI-A in inhibition of solid tumor metastasis: selective targeting of metastatic cells and binding to collagen. Clin Cancer Res. 2003 May;9(5):1898-905. [2]. Inhibition of adhesion, migration and of α5β1 integrin in the HCT-116 colorectal cancer cells treated with the ruthenium drug NAMI-A. J Inorg Biochem. 2016 Jul;160:225-35.

Solubility Data

Solubility (In Vitro)	H2O : ~8.28 mg/mL (~18.07 mM)
Solubility (In Vivo)	Solubility in Formulation 1: 6.67 mg/mL (14.56 mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with sonication (<60°C).  (Please use freshly prepared in vivo formulations for optimal results.)

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	2.1825 mL	10.9127 mL	21.8255 mL
	5 mM	0.4365 mL	2.1825 mL	4.3651 mL
	10 mM	0.2183 mL	1.0913 mL	2.1825 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.