Physicochemical Properties
| Molecular Formula | C18H29NO3 |
| Molecular Weight | 307.43 |
| Exact Mass | 307.215 |
| CAS # | 31078-36-1 |
| PubChem CID | 169252 |
| Appearance | White to off-white solid powder |
| Density | 1.027g/cm3 |
| Boiling Point | 502.9ºC at 760mmHg |
| Flash Point | 257.9ºC |
| Index of Refraction | 1.511 |
| LogP | 4.548 |
| Hydrogen Bond Donor Count | 2 |
| Hydrogen Bond Acceptor Count | 3 |
| Rotatable Bond Count | 11 |
| Heavy Atom Count | 22 |
| Complexity | 296 |
| Defined Atom Stereocenter Count | 0 |
| InChi Key | QLHTWDQJPOTDMV-UHFFFAOYSA-N |
| InChi Code | InChI=1S/C18H29NO3/c1-3-4-5-6-7-8-9-10-18(21)19-14-15-11-12-16(20)17(13-15)22-2/h11-13,20H,3-10,14H2,1-2H3,(H,19,21) |
| Chemical Name | N-[(4-hydroxy-3-methoxyphenyl)methyl]decanamide |
| Synonyms | Decanamide, N-((4-hydroxy-3-methoxyphenyl)methyl)-; N-Vanillyldecanamide |
| HS Tariff Code | 2934.99.9001 |
| Storage |
Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: This product requires protection from light (avoid light exposure) during transportation and storage. |
| Shipping Condition | Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs) |
Biological Activity
| ln Vivo | Capsaicin |
| References |
[1]. Capsaicinoids from hot pepper ( Capsicum annuum L.) and their phytotoxic effect on seedling growth of lettuce ( Lactuca sativa L.). Nat Prod Res. 2020 Jun;34(11):1597-1601. |
| Additional Infomation |
n-Vanillyldecanamide has been reported in Capsicum annuum with data available. See also: Paprika (part of). |
Solubility Data
| Solubility (In Vitro) | DMSO : ~250 mg/mL (~813.19 mM) |
| Solubility (In Vivo) |
Solubility in Formulation 1: 2.08 mg/mL (6.77 mM) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), suspension solution; with sonication. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.8 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.08 mg/mL (6.77 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.8 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. Solubility in Formulation 3: ≥ 2.08 mg/mL (6.77 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.8 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.2528 mL | 16.2639 mL | 32.5277 mL | |
| 5 mM | 0.6506 mL | 3.2528 mL | 6.5055 mL | |
| 10 mM | 0.3253 mL | 1.6264 mL | 3.2528 mL |