N-Acetyl-S-geranylgeranyl-L-cysteine is a methyltransferase inhibitor. N-Acetyl-S-geranylgeranyl-L-cysteine inhibits beta 2 integrin-induced actin polymerization with IC50 of 45 nM.

Physicochemical Properties

Molecular Formula	C25H41NO3S
Molecular Weight	435.66
CAS #	139332-94-8
SMILES	CC(C)=CCC/C(/C)=C/CC/C(/C)=C/CC/C(/C)=C/CSC[C@H](NC(C)=O)C(O)=O
Synonyms	AGGC
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

References

[1]. Inhibitors of farnesyl and geranylgeranyl methyltransferases prevent beta 2 integrin-induced actin polymerization without affecting beta 2 integrin-induced Ca2+ signaling in neutrophils. Biochem Biophys Res Commun. 1996 Jun 25;223(3):612-7.

Solubility Data

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	2.2954 mL	11.4768 mL	22.9537 mL
	5 mM	0.4591 mL	2.2954 mL	4.5907 mL
	10 mM	0.2295 mL	1.1477 mL	2.2954 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.