N-Acetyl-L-tryptophan is an endogenously produced metabolite.

Physicochemical Properties

Molecular Formula	C₁₃H₁₄N₂O₃
Molecular Weight	246.26
Exact Mass	246.1
CAS #	1218-34-4
PubChem CID	700653
Appearance	Typically exists as white to off-white solids at room temperature
Density	1.3±0.1 g/cm3
Boiling Point	586.6±45.0 °C at 760 mmHg
Melting Point	190ºC
Flash Point	308.6±28.7 °C
Vapour Pressure	0.0±1.7 mmHg at 25°C
Index of Refraction	1.645
LogP	0.7
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	3
Rotatable Bond Count	4
Heavy Atom Count	18
Complexity	332
Defined Atom Stereocenter Count	1
SMILES	CC(N[C@H](C(O)=O)CC1=CNC2=CC=CC=C12)=O
InChi Key	DZTHIGRZJZPRDV-LBPRGKRZSA-N
InChi Code	InChI=1S/C13H14N2O3/c1-8(16)15-12(13(17)18)6-9-7-14-11-5-3-2-4-10(9)11/h2-5,7,12,14H,6H2,1H3,(H,15,16)(H,17,18)/t12-/m0/s1
Chemical Name	(2S)-2-acetamido-3-(1H-indol-3-yl)propanoic acid
Synonyms	N-AcetylL tryptophan; N Acetyl L tryptophan; N-Acetyl-L-tryptophan; 1218-34-4; Ac-Trp-OH; Acetyl-L-tryptophan; L-Tryptophan, N-acetyl-; acetyltryptophan; Acetyl-L-trp; (S)-N-Acetyltryptophan;
HS Tariff Code	2934.99.9001
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

Targets	Endogenous Metabolite
ln Vitro	N-acetyl-L-tryptophan is a N-acetyl-L-amino acid that is the N-acetyl derivative of L-tryptophan. It has a role as a metabolite. It is a L-tryptophan derivative and a N-acetyl-L-amino acid. It is a conjugate acid of a N-acetyl-L-tryptophanate. It is an enantiomer of a N-acetyl-D-tryptophan.[1] N-Acetyl-L-tryptophan is a natural product found in Salsola collina and Kali collinum with data available.
References	[1]. https://pubchem.ncbi.nlm.nih.gov/compound/700653
Additional Infomation	N-acetyl-L-tryptophan is a N-acetyl-L-amino acid that is the N-acetyl derivative of L-tryptophan. It has a role as a metabolite. It is a L-tryptophan derivative and a N-acetyl-L-amino acid. It is a conjugate acid of a N-acetyl-L-tryptophanate. It is an enantiomer of a N-acetyl-D-tryptophan. N-Acetyl-L-tryptophan has been reported in Salsola collina and Kali collinum with data available.

Solubility Data

Solubility (In Vitro)

DMSO : ~100 mg/mL (~406.07 mM)

Solubility (In Vivo)

Solubility in Formulation 1: ≥ 2.5 mg/mL (10.15 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (10.15 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. Solubility in Formulation 3: ≥ 2.5 mg/mL (10.15 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly.  (Please use freshly prepared in vivo formulations for optimal results.)

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	4.0607 mL	20.3037 mL	40.6075 mL
	5 mM	0.8121 mL	4.0607 mL	8.1215 mL
	10 mM	0.4061 mL	2.0304 mL	4.0607 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.