AcBut-N-Ac-γ-Calicheamicin is an ADC toxic molecule that induces cell cycle arrest and apoptosis by inducing DNA double-strand breaks. AcBut-N-Ac-γ-Calicheamicin is mainly used to synthesize antibody-drug conjugates (ADCs) and is expected to be used in anti-cancer research, such as acute lymphoblastic leukemia (ALL) and other hematological malignancies.

Physicochemical Properties

Molecular Formula	C77H99IN6O28S3
Molecular Weight	1779.73
CAS #	174885-02-0
Appearance	White to off-white solid powder
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment (e.g. under nitrogen), avoid exposure to moisture and light.
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

References

[1]. Lamb Y N. Inotuzumab ozogamicin: first global approvalJ. Drugs, 2017, 77: 1603-1610.

Solubility Data

Solubility (In Vitro)

DMSO : ≥ 50 mg/mL (~28.09 mM)

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	0.5619 mL	2.8094 mL	5.6188 mL
	5 mM	0.1124 mL	0.5619 mL	1.1238 mL
	10 mM	0.0562 mL	0.2809 mL	0.5619 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.