Morphothiadin (GLS4) mesylate is a potent inhibitor of wild-type and Adefovir-resistant HBV replication with IC50 of 12 nM.

Physicochemical Properties

Molecular Formula	C22H26BRFN4O6S2
Molecular Weight	605.50
CAS #	1646361-04-7
Related CAS #	Morphothiadin;1092970-12-1
SMILES	C1(=C(C=CC(=C1)F)C1C(C(OCC)=O)=C(CN2CCOCC2)N=C(C2SC=CN=2)N1)Br.S(=O)(C)(O)=O
Synonyms	GLS4 mesylate
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

References

[1]. Effects of ketoconazole and rifampicin on the pharmacokinetics of GLS4, a novel anti-hepatitis B virus compound, in dogs. Acta Pharmacol Sin. 2013 Nov;34(11):1420-6. [2]. Preclinical characterization of GLS4, an inhibitor of hepatitis B virus core particle assembly. Antimicrob Agents Chemother. 2013 Nov;57(11):5344-54.

Solubility Data

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	1.6515 mL	8.2576 mL	16.5153 mL
	5 mM	0.3303 mL	1.6515 mL	3.3031 mL
	10 mM	0.1652 mL	0.8258 mL	1.6515 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.