Monosialoganglioside GM3 (bovine) is a monosialoganglioside that is a VEGFR2 and Akt inhibitor. Monosialoganglioside GM3 inhibits angiogenesis and reduces the proliferation and migration of human umbilical vein endothelial cells (HUVECs) at a concentration of 20 μM by inhibiting VEGFR2 and Akt phosphorylation. Ganglioside GM3 also inhibits ferroptosis, thereby playing a protective role in the formation of abdominal aortic aneurysms. In addition, Monosialoganglioside GM3 (bovine) can also act as an insulin signaling inhibitor, inducing the dissociation of the insulin receptor (IR)- Caveolin-1 complex from lipid microdomains and causing insulin resistance in adipocytes. Monosialoganglioside GM3 (bovine) can be used in the study of cancer and metabolic diseases.

Physicochemical Properties

Molecular Formula	C59H106N2NAO21-
Molecular Weight	1202.46
CAS #	54827-14-4
SMILES	CCCCCCCCCCCCC/C=C/[C@H]([C@H](CO[C@@H]1O[C@H](CO)[C@@H](O[C@@H]2O[C@H](CO)[C@H](O)[C@H](O[C@@]3(C[C@H](O)[C@@H](NC(=O)C)[C@H]([C@@H]([C@@H](CO)O)O)O3)C(=O)O)[C@H]2O)[C@H](O)[C@H]1O)NC=O)O
Synonyms	Monosialoganglioside GM3
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

References

[1]. Ganglioside GM3 Protects Against Abdominal Aortic Aneurysm by Suppressing Ferroptosis. Circulation. 2024 Mar 12;149(11):843-859. [2]. Thematic review series: sphingolipids. Ganglioside GM3 suppresses the proangiogenic effects of vascular endothelial growth factor and ganglioside GD1a. J Lipid Res. 2008 May;49(5):929-38. [3]. Ganglioside GM3 Is Antiangiogenic in Malignant Brain Cancer. J Oncol. 2010;2010:961243. [4]. Dissociation of the insulin receptor and caveolin-1 complex by ganglioside GM3 in the state of insulin resistance. Proc Natl Acad Sci U S A. 2007 Aug 21;104(34):13678-83.

Solubility Data

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	0.8316 mL	4.1581 mL	8.3163 mL
	5 mM	0.1663 mL	0.8316 mL	1.6633 mL
	10 mM	0.0832 mL	0.4158 mL	0.8316 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.