Monocaprylin (Glyceryl monocaprylate) is a caprylic acid glycerol monocaprylate with excellent antimicrobial activity. Monocaprylin inhibits a variety of food-borne pathogenic and spoilage microorganisms and may be used in the research of alternative food preservatives.

Physicochemical Properties

Molecular Formula	C₁₁H₂₂O₄
Molecular Weight	218.29
Exact Mass	218.152
CAS #	26402-26-6
PubChem CID	3033877
Appearance	White to off-white solid powder
Density	1.044g/cm3
Boiling Point	340ºC at 760 mmHg
Melting Point	39.0 to 43.0 °C
Flash Point	123.4ºC
Vapour Pressure	5.91E-06mmHg at 25°C
Index of Refraction	1.465
LogP	1.243
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	10
Heavy Atom Count	15
Complexity	159
Defined Atom Stereocenter Count	0
SMILES	O(C([H])([H])C([H])(C([H])([H])O[H])O[H])C(C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])=O
InChi Key	GHBFNMLVSPCDGN-UHFFFAOYSA-N
InChi Code	InChI=1S/C11H22O4/c1-2-3-4-5-6-7-11(14)15-9-10(13)8-12/h10,12-13H,2-9H2,1H3
Chemical Name	2,3-dihydroxypropyl octanoate
HS Tariff Code	2934.99.9001
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment, avoid exposure to moisture.
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

ln Vitro	After 6 hours of incubation, all 5 pathogens (Strep. agalactiae, Strep. dysgalactiae, Strep. uberis, Staph. aureus, and E. coli) are reduced by >5.0 log cfu/mL by monocaprylin (Glyceryl monocaprylate; 25, 50 mM; 24 h)[1].
References	[1]. Antibacterial effect of caprylic acid and monocaprylin on major bacterial mastitis pathogens. J Dairy Sci. 2005 Oct;88(10):3488-95.
Additional Infomation	1-monooctanoylglycerol is a 1-monoglyceride that has octanoyl as the acyl group. It is a 1-monoglyceride and an octanoate ester. See also: Monoctanoin (annotation moved to).

Solubility Data

Solubility (In Vitro)

DMSO : 100 mg/mL (458.11 mM)

Solubility (In Vivo)

Solubility in Formulation 1: ≥ 2.5 mg/mL (11.45 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly.  (Please use freshly prepared in vivo formulations for optimal results.)

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	4.5811 mL	22.9053 mL	45.8106 mL
	5 mM	0.9162 mL	4.5811 mL	9.1621 mL
	10 mM	0.4581 mL	2.2905 mL	4.5811 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.