Mitoridine is a naturally occurring indole alkaloid extracted from the stem bark of Rauwolfia cumminsii Stapf.

Physicochemical Properties

Molecular Formula	C20H22N2O2
Molecular Weight	322.40088
Exact Mass	322.168
CAS #	3911-19-1
PubChem CID	101297641
Appearance	Light yellow to yellow solid powder
Density	1.4±0.1 g/cm3
Boiling Point	522.1±50.0 °C at 760 mmHg
Melting Point	322℃
Flash Point	269.6±30.1 °C
Vapour Pressure	0.0±1.4 mmHg at 25°C
Index of Refraction	1.722
LogP	2.05
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	0
Heavy Atom Count	24
Complexity	660
Defined Atom Stereocenter Count	4
SMILES	C/C=C/1\CN2[C@H]3CC45[C@H](C2C[C@@H]1[C@@H]3C4=O)N(C6=C5C=CC=C6O)C
InChi Key	VVLPFXAEVKKWTK-JTJLKIRNSA-N
InChi Code	InChI=1S/C20H22N2O2/c1-3-10-9-22-13-7-11(10)16-14(22)8-20(19(16)24)12-5-4-6-15(23)17(12)21(2)18(13)20/h3-6,11,13-14,16,18,23H,7-9H2,1-2H3/b10-3+/t11-,13?,14-,16-,18-,20?/m0/s1
Chemical Name	(9R,12R,13Z,16S,17S)-13-ethylidene-6-hydroxy-8-methyl-8,15-diazahexacyclo[14.2.1.01,9.02,7.010,15.012,17]nonadeca-2(7),3,5-trien-18-one
HS Tariff Code	2934.99.9001
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: This product requires protection from light (avoid light exposure) during transportation and storage.
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

References

[1]. Na-demethyl-purpeline and Na-demethyl-dihydropurpeline, new alkaloids from Rauwolfia cumminsii Stapf. Experientia. 1977;33(10):1268.

Solubility Data

Solubility (In Vitro)

DMSO : ~20 mg/mL (~62.03 mM)

Solubility (In Vivo)

Solubility in Formulation 1: ≥ 2 mg/mL (6.20 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.0 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly.  (Please use freshly prepared in vivo formulations for optimal results.)

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	3.1017 mL	15.5087 mL	31.0174 mL
	5 mM	0.6203 mL	3.1017 mL	6.2035 mL
	10 mM	0.3102 mL	1.5509 mL	3.1017 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.