Minodronic acid (YM-529) is a third-generation bisphosphate that directly or indirectly prevents proliferation, causes apoptosis, and inhibits the metastasis of various types of cancer cells. Minodronic acid (YM-529) is a purine P2X2/3 receptor antagonist involved in pain.

Physicochemical Properties

Molecular Formula	C9H12N2O7P2
Molecular Weight	322.15
Exact Mass	322.012
CAS #	180064-38-4
Related CAS #	Minodronic acid-d4;1807367-80-1
PubChem CID	130956
Appearance	White to off-white solid powder
Density	1.973 g/cm3
LogP	-2.2
Hydrogen Bond Donor Count	5
Hydrogen Bond Acceptor Count	8
Rotatable Bond Count	4
Heavy Atom Count	20
Complexity	439
Defined Atom Stereocenter Count	0
InChi Key	VMMKGHQPQIEGSQ-UHFFFAOYSA-N
InChi Code	InChI=1S/C9H12N2O7P2/c12-9(19(13,14)15,20(16,17)18)5-7-6-10-8-3-1-2-4-11(7)8/h1-4,6,12H,5H2,(H2,13,14,15)(H2,16,17,18)
Chemical Name	(1-hydroxy-2-imidazo[1,2-a]pyridin-3-yl-1-phosphonoethyl)phosphonic acid
HS Tariff Code	2934.99.9001
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

Targets	P2X2/3[2]
References	[1]. A third-generation bisphosphonate, minodronic acid (YM529), successfully prevented the growth of bladder cancer in vitro and in vivo. Br J Cancer. 2006 Nov 20;95(10):1354-61. [2]. Minodronic acid induces morphological changes in osteoclasts at bone resorption sites and reaches a level required for antagonism of purinergic P2X2/3 receptors. J Bone Miner Metab. 2018 Jan;36(1):54-63.
Additional Infomation	See also: Minodronic acid monohydrate (annotation moved to). Drug Indication Investigated for use/treatment in multiple myeloma, breast cancer, osteoporosis, and lung cancer.

Solubility Data

Solubility (In Vitro)	H2O : 5 mg/mL (15.52 mM ) DMSO : < 1 mg/mL
Solubility (In Vivo)	Solubility in Formulation 1: 2 mg/mL (6.21 mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with sonication.  (Please use freshly prepared in vivo formulations for optimal results.)

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	3.1041 mL	15.5207 mL	31.0414 mL
	5 mM	0.6208 mL	3.1041 mL	6.2083 mL
	10 mM	0.3104 mL	1.5521 mL	3.1041 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.