Methyl piperazine-2-carboxylate (compound 4) is a potent METTL3/METTL14/WTAP activator. Methyl piperazine-2-carboxylate increases the production of HIV-1 p24 virions. Methyl piperazine-2-carboxylate increases the N6-adenosine methylation level in the viral RNA genome.

Physicochemical Properties

Molecular Formula	C6H12N2O2
Molecular Weight	144.17
CAS #	2758-98-7
SMILES	COC(=O)C1CNCCN1
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

References

[1]. HIV Replication Is Increased by RNA Methylation METTL3/METTL14/WTAP Complex Activators. ACS Omega. 2021 Jun 11;6(24):15957-15963.

Solubility Data

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	6.9363 mL	34.6813 mL	69.3626 mL
	5 mM	1.3873 mL	6.9363 mL	13.8725 mL
	10 mM	0.6936 mL	3.4681 mL	6.9363 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.