Methyl clofenapate (Clofenapate methyl ester; MCP) is a peroxisome proliferator that can induce hypolipidemia, peroxisome proliferation, and hepatocarcinogenesis.

Physicochemical Properties

Molecular Formula	C17H17CLO3
Molecular Weight	304.77
Exact Mass	304.087
CAS #	21340-68-1
PubChem CID	30602
Appearance	Solid powder
Density	1.171g/cm3
Boiling Point	407ºC at 760 mmHg
Flash Point	151.5ºC
Vapour Pressure	7.77E-07mmHg at 25°C
Index of Refraction	1.548
LogP	4.337
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	3
Rotatable Bond Count	5
Heavy Atom Count	21
Complexity	340
Defined Atom Stereocenter Count	0
SMILES	CC(C)(C(=O)OC)OC1=CC=C(C=C1)C2=CC=C(C=C2)Cl
InChi Key	CLJAWWBXVXWHFD-UHFFFAOYSA-N
InChi Code	InChI=1S/C17H17ClO3/c1-17(2,16(19)20-3)21-15-10-6-13(7-11-15)12-4-8-14(18)9-5-12/h4-11H,1-3H3
Chemical Name	methyl 2-[4-(4-chlorophenyl)phenoxy]-2-methylpropanoate
Synonyms	Clofenapate methyl ester; MCP
HS Tariff Code	2934.99.9001
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

References	[1]. Comparative effects of clofibrate and methyl clofenapate on morphological transformation and intercellular communication of Syrian hamster embryo cells. Carcinogenesis. 1997 Apr;18(4):701-6.
Additional Infomation	Methyl clofenapate is a white powder. (NTP, 1992) An oral hypolipemic agent primarily used in DOGS and RATS.

Solubility Data

Solubility (In Vitro)	DMSO : 100 mg/mL (328.12 mM; with sonication)
Solubility (In Vivo)	Solubility in Formulation 1: 5 mg/mL (16.41 mM) in 10% DMSO 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution; sonication. For example, if 1 mL of working solution, add 100 μL of 50.0 mg/mL clear DMSO stock solution to 900 μL corn oil and mix well. (Please use freshly prepared in vivo formulations for optimal results.)

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	3.2812 mL	16.4058 mL	32.8116 mL
	5 mM	0.6562 mL	3.2812 mL	6.5623 mL
	10 mM	0.3281 mL	1.6406 mL	3.2812 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.