Meprednisone (formerly NSC-527579; SCH-4358; NSC63278; SCH4358; Betapar; Medrysone) is a glucocorticoid and a methylated derivative of prednisone acting as a glucocorticoid receptor agonist and has been approved for use to treat allergic and inflammatory of the eye.

Physicochemical Properties

Molecular Formula	C22H28O5
Molecular Weight	372.45
Exact Mass	372.193
CAS #	1247-42-3
Related CAS #	1247-42-3
PubChem CID	5284587
Appearance	White to off-white solid powder
Density	1.3±0.1 g/cm3
Boiling Point	574.4±50.0 °C at 760 mmHg
Melting Point	204-206ºC
Flash Point	315.2±26.6 °C
Vapour Pressure	0.0±3.6 mmHg at 25°C
Index of Refraction	1.595
LogP	2.06
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	2
Heavy Atom Count	27
Complexity	795
Defined Atom Stereocenter Count	7
SMILES	C[C@@]1(C2)[C@](C(CO)=O)(O)[C@@H](C)C[C@@]1([H])[C@]3([H])CCC4=CC(C=C[C@]4(C)[C@@]3([H])C2=O)=O
InChi Key	PIDANAQULIKBQS-RNUIGHNZSA-N
InChi Code	InChI=1S/C22H28O5/c1-12-8-16-15-5-4-13-9-14(24)6-7-20(13,2)19(15)17(25)10-21(16,3)22(12,27)18(26)11-23/h6-7,9,12,15-16,19,23,27H,4-5,8,10-11H2,1-3H3/t12-,15-,16-,19+,20-,21-,22-/m0/s1
Chemical Name	(8S,9S,10R,13S,14S,16S,17R)-17-hydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-7,8,9,10,12,13,14,15,16,17-decahydro-3H-cyclopenta[a]phenanthrene-3,11(6H)-dione
Synonyms	NSC-63278; Betapar; Medrysone;NSC 63278; NSC63278
HS Tariff Code	2934.99.9001
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: This product requires protection from light (avoid light exposure) during transportation and storage.
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

References	Am J Contact Dermat.2003 Dec;14(4):179-87.
Additional Infomation	Meprednisone is a 21-hydroxy steroid.

Solubility Data

Solubility (In Vitro)

DMSO:75 mg/mL (201.3 mM) Water:<1 mg/mL Ethanol:4 mg/mL (10.7 mM)

Solubility (In Vivo)

Solubility in Formulation 1: ≥ 3 mg/mL (8.05 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 30.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 3 mg/mL (8.05 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 30.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. Solubility in Formulation 3: ≥ 3 mg/mL (8.05 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 30.0 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly.  (Please use freshly prepared in vivo formulations for optimal results.)

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	2.6849 mL	13.4246 mL	26.8492 mL
	5 mM	0.5370 mL	2.6849 mL	5.3698 mL
	10 mM	0.2685 mL	1.3425 mL	2.6849 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.