MenA-IN-2 (Compound 11) is a 1,4-dihydroxy-2-naphtholate isoprenyltransferase (MenA) inhibitor. MenA-IN-2 inhibits MenA with IC50 of 22 µM and MenA-IN-2 against Mycobacterium tuberculosis (Mtb) with a GIC50 of 10 µM. MenA-IN-2 can inhibit the continued spread of Mtb.

Physicochemical Properties

Molecular Formula	C23H31CLN2O
Appearance	Typically exists as solid at room temperature
HS Tariff Code	2934.99.9001
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

Targets	IC50: 22 µM (1,4-dihydroxy-2-naphthoate prenyltransferase, MenA)[1]
References	[1]. Berg K, et al. SAR study of piperidine derivatives as inhibitors of 1,4-dihydroxy-2-naphthoate isoprenyltransferase (MenA) from Mycobacterium tuberculosis. Eur J Med Chem. 2023 Jan 18;249:115125.

Solubility Data

Solubility (In Vitro)

DMSO :~250 mg/mL (~646.06 mM)

Solubility (In Vivo)

Solubility in Formulation 1: ≥ 2.08 mg/mL (5.38 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.8 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly.  (Please use freshly prepared in vivo formulations for optimal results.)