Meclofenoxate (also known as Centrophenoxine) HCl is a potent nootropic agent and an anti-aging drug used to treat the symptoms of senile dementia and Alzheimer's disease, and also inhibits the activity of cholinephosphotransferase. Meclofenoxate hydrochloride, an ester of dimethylethanolamine (DMAE) and 4-chlorophenoxyacetic acid (pCPA), has been shown to improve memory, have a mentally stimulating effect, and improve general cognition.

Physicochemical Properties

Molecular Formula	C12H17CL2NO3
Molecular Weight	294.17
Exact Mass	293.058
CAS #	3685-84-5
Related CAS #	3685-84-5
PubChem CID	19379
Appearance	White to off-white solid powder
Boiling Point	345.9ºC at 760mmHg
Melting Point	133-135°C
LogP	2.625
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	7
Heavy Atom Count	18
Complexity	228
Defined Atom Stereocenter Count	0
InChi Key	FIVHOHCAXWQPGC-UHFFFAOYSA-N
InChi Code	InChI=1S/C12H16ClNO3.ClH/c1-14(2)7-8-16-12(15)9-17-11-5-3-10(13)4-6-11;/h3-6H,7-9H2,1-2H3;1H
Chemical Name	2-(Dimethylamino)ethyl 2-(4-chlorophenoxy)acetate hydrochloride
Synonyms	Meclofenoxate HCl; Centrophenoxine HCl; Centrophenoxine; Cerutil, Lucidril; Helfergin; Marucotol; Acefen; Atsefen; Brenal
HS Tariff Code	2934.99.9001
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment, avoid exposure to moisture.
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

References	Age Ageing.1977 May;6(2):123-31.
Additional Infomation	An ester of DIMETHYLAMINOETHANOL and para-chlorophenoxyacetic acid.

Solubility Data

Solubility (In Vitro)	DMSO:58 mg/mL (197.2 mM) Water:58 mg/mL (197.2 mM) Ethanol: N/A
Solubility (In Vivo)	Solubility in Formulation 1: 100 mg/mL (339.94 mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with sonication.  (Please use freshly prepared in vivo formulations for optimal results.)

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	3.3994 mL	16.9970 mL	33.9939 mL
	5 mM	0.6799 mL	3.3994 mL	6.7988 mL
	10 mM	0.3399 mL	1.6997 mL	3.3994 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.