Meclofenamate Sodium (Meclonax; Meclomen; INF-4668; INF4668; CI 583; CI-583; Meclodium; Meclofenamic acid sodium) is a potent nonsteroidal anti-inflammatory drug (NSAID), acting as a dual COX-1/COX-2 inhibitor with IC50 of 40 nM and 50 nM, respectively. It is used in the treatment of joint, muscular pain, arthritis and dysmenorrhea. Meclofenamate sodium is a potent nonsteroidal antiinflammatory agent, specifically inhibits chemotactic factor-induced human polymorphonuclear leukocyte functions: chemotaxis, degranulation, and generation of superoxide anion radicals. These effects of MSM were found to be dependent upon the concentrations of drug not bound to albumin (free drug), and were caused by its ability to interfere at both a receptor and post-receptor level.

Physicochemical Properties

Molecular Formula	C14H11CL2NO2.NA
Molecular Weight	318.13
Exact Mass	335.009
CAS #	6385-02-0
Related CAS #	Meclofenamic acid;644-62-2
PubChem CID	4038
Appearance	White to off-white solid powder
Boiling Point	399.4ºC at 760 mmHg
Melting Point	287 °C
Flash Point	195.3ºC
LogP	3.481
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	3
Rotatable Bond Count	3
Heavy Atom Count	20
Complexity	332
Defined Atom Stereocenter Count	0
InChi Key	QHJLLDJTVQAFAN-UHFFFAOYSA-M
InChi Code	InChI=1S/C14H11Cl2NO2.Na.H2O/c1-8-6-7-10(15)13(12(8)16)17-11-5-3-2-4-9(11)14(18)19;;/h2-7,17H,1H3,(H,18,19);;1H2/q;+1;/p-1
Chemical Name	sodium 2-((2,6-dichloro-3-methylphenyl)amino)benzoate hydrate
Synonyms	INF 4668; CI583; Meclonax; Meclomen; INF-4668; INF4668; CI 583; CI-583;Meclodium; Sodium meclophenamate; Sodium meclofenamate
HS Tariff Code	2934.99.9001
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment (e.g. under nitrogen), avoid exposure to moisture and light.
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

Toxicity/Toxicokinetics	Effects During Pregnancy and Lactation ◉ Summary of Use during Lactation Because no information is available on the use of meclofenamate during breastfeeding, other agents may be preferred, especially while nursing a newborn or preterm infant. ◉ Effects in Breastfed Infants Relevant published information was not found as of the revision date. ◉ Effects on Lactation and Breastmilk Relevant published information was not found as of the revision date.
References	J Mol Cell Cardiol.2016May;94:131-44;
Additional Infomation	Sodium meclofenamate (anhydrous) is an organic sodium salt. It contains a meclofenamic acid(1-). A non-steroidal anti-inflammatory agent with antipyretic and antigranulation activities. It also inhibits prostaglandin biosynthesis. See also: Meclofenamate Sodium (annotation moved to).

Solubility Data

Solubility (In Vitro)

DMSO: 63 mg/mL (198.0 mM) Water: N/A Ethanol:63 mg/mL (198.0 mM)

Solubility (In Vivo)

Solubility in Formulation 1: ≥ 2.08 mg/mL (6.54 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.8 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.08 mg/mL (6.54 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.8 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. Solubility in Formulation 3: ≥ 2.08 mg/mL (6.54 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.8 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly.  (Please use freshly prepared in vivo formulations for optimal results.)

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	3.1434 mL	15.7168 mL	31.4337 mL
	5 mM	0.6287 mL	3.1434 mL	6.2867 mL
	10 mM	0.3143 mL	1.5717 mL	3.1434 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.