Mc-Pro-PAB-MMAE is a drug-linker conjugate for ADC. Mc-Pro-PAB-MMAE is composed of Monomethyl auristatin E and a linker. Mc-Pro-PAB-MMAE can be used in the synthesis of ADCs.

Physicochemical Properties

Molecular Formula	C64H95N9O14
Molecular Weight	1214.49
CAS #	2766450-03-5
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

References

[1]. Fibroblast activation protein ligands for targeted delivery applications. Patent, WO2021160825, 2021-08-19. [2]. In vivo activation of FAP-cleavable small molecule-drug conjugates for the targeted delivery of camptothecins and tubulin poisons to the tumor microenvironmentJ. Journal of Controlled Release, 2024, 367: 779-790.

Solubility Data

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	0.8234 mL	4.1170 mL	8.2339 mL
	5 mM	0.1647 mL	0.8234 mL	1.6468 mL
	10 mM	0.0823 mL	0.4117 mL	0.8234 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.