Maytansine derivative M24 is a drug-linker conjugate for ADC, which can be used to synthesize ADC REGN5093-M114.

Physicochemical Properties

Molecular Formula	C61H86CLN9O18
Molecular Weight	1268.84
CAS #	2226467-81-6
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

References

[1]. EP10. 01-03 A Phase 1/2 Study of REGN5093-M114, a METxMET Antibody-Drug Conjugate, in Patients with MET-Overexpressing NSCLC. Journal of Thoracic Oncology, 2023, 18(11): S602-S603.

Solubility Data

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	0.7881 mL	3.9406 mL	7.8812 mL
	5 mM	0.1576 mL	0.7881 mL	1.5762 mL
	10 mM	0.0788 mL	0.3941 mL	0.7881 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.