Mal-VC-PAB-DMEA-PNU-159682 is an agent-linker conjugate for ADCs, which has potent antitumor activity by linking the anti-topoisomerase II inhibitor PNU-159682 to the lysosomal cleavable dipeptide Mc-VC-PAB. Mal-VC-PAB-DMEA-PNU-159682 can be used to synthesize Anti-CD22-NMS249.

Physicochemical Properties

Molecular Formula	C66H83N9O22
Molecular Weight	1354.41
CAS #	1178887-17-6
Synonyms	SET0568
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

References

[1]. A Novel Anti-CD22 Anthracycline-Based Antibody-Drug Conjugate (ADC) That Overcomes Resistance to Auristatin-Based ADCs. Clin Cancer Res. 2015 Jul 15;21(14):3298-306.

Solubility Data

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	0.7383 mL	3.6916 mL	7.3833 mL
	5 mM	0.1477 mL	0.7383 mL	1.4767 mL
	10 mM	0.0738 mL	0.3692 mL	0.7383 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.