Mal-PEG4-Val-Cit-PAB-MMAE is part of the drug-linker conjugate for ADC. Mal-PEG4-Val-Cit-PAB-MMAE contains a degradable ADC linker Mal-PEG4-Val-Cit-PAB and a potent tubulin inhibitor MMAE.

Physicochemical Properties

Molecular Formula	C73H115N11O19
Molecular Weight	1450.76
Appearance	White to off-white solid powder
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: (1). This product is not stable in solution, please use freshly prepared working solution for optimal results.(2). Please store this product in a sealed and protected environment, avoid exposure to moisture.
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

References

[1]. Strategies and challenges for the next generation of antibody–drug conjugatesJ. Nature reviews Drug discovery, 2017, 16(5): 315-337.

Solubility Data

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	0.6893 mL	3.4465 mL	6.8929 mL
	5 mM	0.1379 mL	0.6893 mL	1.3786 mL
	10 mM	0.0689 mL	0.3446 mL	0.6893 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.