Mal-GGFG-PAB-MMAE (Compound 8) is a drug-linker conjugate composed of the mitotic inhibitor MMAE and the linker Mal-GGFG-PAB. Mal-GGFG-PAB-MMAE can be used to synthesize antibody-drug conjugates.

Physicochemical Properties

Molecular Formula	C69H97N11O16
Molecular Weight	1336.57
CAS #	3055607-18-3
Appearance	White to off-white solid powder
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment (e.g. under nitrogen), avoid exposure to moisture and light.
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

References

[1]. Highly stable targeted linker-drug conjugate. US20240293570.

Solubility Data

Solubility (In Vitro)

DMSO : ≥ 100 mg/mL (~74.82 mM)

Solubility (In Vivo)

Solubility in Formulation 1: ≥ 2.5 mg/mL (1.87 mM)(saturation unknown) in 10% DMSO 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one),clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution and add it to 900 μL corn oil and mix well.  (Please use freshly prepared in vivo formulations for optimal results.)

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	0.7482 mL	3.7409 mL	7.4818 mL
	5 mM	0.1496 mL	0.7482 mL	1.4964 mL
	10 mM	0.0748 mL	0.3741 mL	0.7482 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.