MS7972 is a small molecule that blocks the binding of human p53 to CREB. MS7972 almost completely blocks the BRD interaction at 50 μM.

Physicochemical Properties

Molecular Formula	C14H13NO2
Molecular Weight	227.259
Exact Mass	227.094
Elemental Analysis	C, 73.99; H, 5.77; N, 6.16; O, 14.08
CAS #	352553-42-5
Related CAS #	352553-42-5
PubChem CID	853608
Appearance	Light yellow to yellow solid powder
LogP	2.3
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	2
Rotatable Bond Count	0
Heavy Atom Count	17
Complexity	352
Defined Atom Stereocenter Count	0
InChi Key	MIGJEXKBUJPKJF-UHFFFAOYSA-N
InChi Code	InChI=1S/C14H13NO2/c1-9(16)15-12-7-3-2-5-10(12)11-6-4-8-13(17)14(11)15/h2-3,5,7H,4,6,8H2,1H3
Chemical Name	9-acetyl-3,4-dihydro-2H-carbazol-1-one
Synonyms	MS7972; MS 7972; MS-7972
HS Tariff Code	2934.99.9001
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

ln Vitro	When MS7972 is added to CBP BRD, resonance energy transfer causes emission at 445 nm and CBP BRD to be quenched [1].
References	[1]. Target structure-based discovery of small molecules that block human p53 and CREB binding protein association. Chem Biol. 2006 Jan;13(1):81-90.

Solubility Data

Solubility (In Vitro)

DMSO: 45~100 mg/mL(198.0~440.0 mM) Ethanol: ~11 mg/mL(~48.4 mM)

Solubility (In Vivo)

Solubility in Formulation 1: ≥ 2.5 mg/mL (11.00 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly.  (Please use freshly prepared in vivo formulations for optimal results.)

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	4.4002 mL	22.0012 mL	44.0025 mL
	5 mM	0.8800 mL	4.4002 mL	8.8005 mL
	10 mM	0.4400 mL	2.2001 mL	4.4002 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.