PeptideDB

MORF-627 2412688-16-3

MORF-627 2412688-16-3

CAS No.: 2412688-16-3

MORF-627 is an orally available, selective inhibitor of integrin αvβ6 with an IC50 of 9.2 nM as measured by human seru
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MORF-627 is an orally available, selective inhibitor of integrin αvβ6 with an IC50 of 9.2 nM as measured by human serum ligand binding assay. MORF-627 inhibits αvβ6-mediated TGF-β1 activation with an IC50 of 2.63 nM and SMAD2/3 phosphorylation with an IC50 of 8.3 nM. MORF-627 improves Bleomycin-induced pulmonary fibrosis in mice.

Physicochemical Properties


Molecular Formula C31H40FN3O4
Molecular Weight 537.67
CAS # 2412688-16-3
Storage

Powder-20°C 3 years

4°C 2 years

In solvent -80°C 6 months

-20°C 1 month

Shipping Condition Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity


Targets αvβ6 9.2 nM (IC50)
References

[1]. The Discovery of MORF-627, a Highly Selective Conformationally-Biased Zwitterionic Integrin αvβ6 Inhibitor for Fibrosis. J Med Chem. 2024 Nov 14;67(21):18656-18681.


Solubility Data


Preparing Stock Solutions 1 mg 5 mg 10 mg
1 mM 1.8599 mL 9.2994 mL 18.5988 mL
5 mM 0.3720 mL 1.8599 mL 3.7198 mL
10 mM 0.1860 mL 0.9299 mL 1.8599 mL
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.