MOMBA is a selective orthosteric agonist of FFA2 (Free Fatty Acid Receptor 2) that activates the receptor signaling pathway by binding to the orthosteric site of FFA2 with high specificity. MOMBA is expected to be used in the study of metabolic and inflammatory diseases.

Physicochemical Properties

Molecular Formula	C9H10O3
Molecular Weight	166.18
CAS #	6880-04-2
Appearance	White to off-white solid powder
SMILES	O(C([H])([H])[H])C1C([H])=C([H])C(C(=O)O[H])=C([H])C=1C([H])([H])[H]
Synonyms	3-Methyl-p-methoxybenzoic acid
HS Tariff Code	2934.99.9001
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

References

[1]. Chemogenetic Approaches to Explore the Functions of Free Fatty Acid Receptor 2. Trends Pharmacol Sci. 2021 Mar;42(3):191-202.

Solubility Data

Solubility (In Vitro)

DMSO : ~200 mg/mL (~1203.51 mM; with ultrasonication)

Solubility (In Vivo)

Solubility in Formulation 1: ≥ 5 mg/mL (30.09 mM)(saturation unknown) in 10% DMSO 40% PEG300 5% Tween-80 45% Saline (add these co-solvents sequentially from left to right, and one by one),clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 50.0 mg/mL clear DMSO stock solution and add it to 400 μL PEG300, mix well; then add 50 μL Tween-80 to the above system, mix well; then continue to add 450 μL of normal saline to make up to 1 mL. Preparation of normal saline: Dissolve 0.9 g of sodium chloride in ddH₂O and make up to 100 mL to obtain a clear and transparent normal saline solution. Solubility in Formulation 2: ≥ 5 mg/mL (30.09 mM)(saturation unknown) in 10% DMSO 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one),clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 50.0 mg/mL clear DMSO stock solution and add it to 900 μL of 20% SBE-β-CD saline solution and mix well. 2 g SBE-β-CD (sulfobutyl ether β-cyclodextrin) powder is diluted to 10 mL of saline and completely dissolved until clear and transparent. Solubility in Formulation 3: ≥ 5 mg/mL (30.09 mM)(saturation unknown) in 10% DMSO 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one),clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 50.0 mg/mL clear DMSO stock solution and add it to 900 μL corn oil and mix well.  (Please use freshly prepared in vivo formulations for optimal results.)

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	6.0176 mL	30.0879 mL	60.1757 mL
	5 mM	1.2035 mL	6.0176 mL	12.0351 mL
	10 mM	0.6018 mL	3.0088 mL	6.0176 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.