MAPI is a polypeptide irreversible 3C cysteine protease (SV3CP) inhibitor. MAPI inhibits SV3CP by covalently binding its C-terminal Michael acceptor extension to the active site thiol of SV3CP Cys 139. MAPI has the potential to be used in the study of norovirus infection.

Physicochemical Properties

Molecular Formula	C36H53N7O11
Molecular Weight	759.85
CAS #	1260620-30-1
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

References

[1]. A structural study of norovirus 3C protease specificity: binding of a designed active site-directed peptide inhibitor. Biochemistry. 2011 Jan 18;50(2):240-9.

Solubility Data

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	1.3160 mL	6.5802 mL	13.1605 mL
	5 mM	0.2632 mL	1.3160 mL	2.6321 mL
	10 mM	0.1316 mL	0.6580 mL	1.3160 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.