LysRs-IN-1 is an inhibitor (blocker/antagonist) of lysine-tRNA synthetase (LysRs).

Physicochemical Properties

Molecular Formula	C7H7N5O3
Molecular Weight	209.16218
Exact Mass	209.055
CAS #	281676-77-5
PubChem CID	135731675
Appearance	Off-white to light yellow solid powder
LogP	-1.4
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	2
Heavy Atom Count	15
Complexity	342
Defined Atom Stereocenter Count	0
InChi Key	PJFWBSLAJQMJJS-UHFFFAOYSA-N
InChi Code	InChI=1S/C7H7N5O3/c8-7-10-5-4(6(15)11-7)9-2-12(5)1-3(13)14/h2H,1H2,(H,13,14)(H3,8,10,11,15)
Chemical Name	2-(2-amino-6-oxo-1H-purin-9-yl)acetic acid
HS Tariff Code	2934.99.9001
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

References	[1]. Looking Deep Inside: Detection of Low-Abundance Proteins in Leaf Extracts of Arabidopsis and Phloem Exudates of Pumpkin. Plant Physiol. 2012 Jul; 159(3): 902–914.
Additional Infomation	The selected literature [1] focuses on developing methods for detecting low-abundance proteins in Arabidopsis leaf extracts and pumpkin phloem exudates. It describes experimental workflows for protein extraction, enrichment, and mass spectrometry-based identification, aiming to improve the detection sensitivity of rare plant proteins [1]

Solubility Data

Solubility (In Vitro)

DMSO : ~83.33 mg/mL (~398.40 mM)

Solubility (In Vivo)

Solubility in Formulation 1: ≥ 2.08 mg/mL (9.94 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.8 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. Solubility in Formulation 2: ≥ 2.08 mg/mL (9.94 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.8 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly.  (Please use freshly prepared in vivo formulations for optimal results.)

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	4.7810 mL	23.9051 mL	47.8103 mL
	5 mM	0.9562 mL	4.7810 mL	9.5621 mL
	10 mM	0.4781 mL	2.3905 mL	4.7810 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.