Linoleoyl glycine is a modified polyunsaturated fatty acid. Linoleoyl glycine activates the human KCNQ1/KCNE1 (hKCNQ1/hKCNE1) channel expressed in Xenopus oocytes.

Physicochemical Properties

Molecular Formula	C20H35NO3
Molecular Weight	337.4968
Exact Mass	337.261
CAS #	2764-03-6
PubChem CID	6433346
Appearance	Typically exists as solid at room temperature
Density	1.0±0.1 g/cm3
Boiling Point	530.7±43.0 °C at 760 mmHg
Flash Point	274.8±28.2 °C
Vapour Pressure	0.0±3.0 mmHg at 25°C
Index of Refraction	1.489
LogP	6.05
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	3
Rotatable Bond Count	16
Heavy Atom Count	24
Complexity	375
Defined Atom Stereocenter Count	0
SMILES	CCCCC/C=C\C/C=C\CCCCCCCC(NCC(O)=O)=O
InChi Key	YCRHZEHWEYAHCO-HZJYTTRNSA-N
InChi Code	InChI=1S/C20H35NO3/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-19(22)21-18-20(23)24/h6-7,9-10H,2-5,8,11-18H2,1H3,(H,21,22)(H,23,24)/b7-6-,10-9-
Chemical Name	2-[[(9Z,12Z)-octadeca-9,12-dienoyl]amino]acetic acid
HS Tariff Code	2934.99.9001
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

Additional Infomation

N-linoleoylglycine is a N-acyl-amino acid. It is a conjugate acid of a N-linoleoylglycine(1-).

Solubility Data

Solubility (In Vitro)

DMSO : ~125 mg/mL (~370.37 mM)

Solubility (In Vivo)

Solubility in Formulation 1: ≥ 2.08 mg/mL (6.16 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.8 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: 2.08 mg/mL (6.16 mM) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), suspension solution; with ultrasonication. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.8 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. Solubility in Formulation 3: ≥ 2.08 mg/mL (6.16 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.8 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly.  (Please use freshly prepared in vivo formulations for optimal results.)

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	2.9630 mL	14.8148 mL	29.6296 mL
	5 mM	0.5926 mL	2.9630 mL	5.9259 mL
	10 mM	0.2963 mL	1.4815 mL	2.9630 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.