Licoflavone B is a novel and potent flavonoid isolated from Glycyrrhiza inflata. Licoflavone B inhibits S. mansoni ATPase (IC50, 23.78 µM) and ADPase (IC50, 31.50 µM) activity.
Physicochemical Properties
| Molecular Formula | C25H26O4 |
| Molecular Weight | 390.4715 |
| Exact Mass | 390.183 |
| CAS # | 91433-17-9 |
| PubChem CID | 11349817 |
| Appearance | White to yellow solid powder |
| Density | 1.191±0.06 g/cm3(Predicted) |
| Boiling Point | 593.9±50.0 °C(Predicted) |
| LogP | 6.3 |
| Hydrogen Bond Donor Count | 2 |
| Hydrogen Bond Acceptor Count | 4 |
| Rotatable Bond Count | 5 |
| Heavy Atom Count | 29 |
| Complexity | 681 |
| Defined Atom Stereocenter Count | 0 |
| InChi Key | GLDVIKFETPAZNV-UHFFFAOYSA-N |
| InChi Code | InChI=1S/C25H26O4/c1-15(2)5-7-17-11-19(9-10-21(17)26)24-14-23(28)20-12-18(8-6-16(3)4)22(27)13-25(20)29-24/h5-6,9-14,26-27H,7-8H2,1-4H3 |
| Chemical Name | 7-hydroxy-2-[4-hydroxy-3-(3-methylbut-2-enyl)phenyl]-6-(3-methylbut-2-enyl)chromen-4-one |
| Synonyms | Licoflavone B; Prenyllicoflavone A; VMN9VGP9XJ; |
| HS Tariff Code | 2934.99.9001 |
| Storage |
Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: This product requires protection from light (avoid light exposure) during transportation and storage. |
| Shipping Condition | Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs) |
Biological Activity
| References |
[1]. Schistosomicidal activity and docking of Schistosoma mansoni ATPDase 1 with licoflavone B isolated from Glycyrrhiza inflata (Fabaceae). |
| Additional Infomation |
Licoflavone B is a member of flavones. Licoflavone B has been reported in Lupinus albus, Glycyrrhiza glabra, and Glycyrrhiza inflata with data available. See also: Glycyrrhiza inflata root (part of). |
Solubility Data
| Solubility (In Vitro) | DMSO : ~100 mg/mL (~256.10 mM) |
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (6.40 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.5610 mL | 12.8051 mL | 25.6102 mL | |
| 5 mM | 0.5122 mL | 2.5610 mL | 5.1220 mL | |
| 10 mM | 0.2561 mL | 1.2805 mL | 2.5610 mL |