Levofloxacin mesylate is an orally active antibiotic with inhibitory effects on both gram-positive and gram-negative bacteria. Levofloxacin mesylate inhibits DNA gyrase and topoisomerase IV. Levofloxacin mesylate is useful in the study of chronic periodontitis, airway inflammation, and BK viremia. Levofloxacin mesylate has anti-orthopoxic activity.

Physicochemical Properties

Molecular Formula	C19H24FN3O7S
Molecular Weight	457.47
CAS #	226578-51-4
Related CAS #	Levofloxacin;100986-85-4
SMILES	S(C([H])([H])[H])(=O)(=O)O[H].FC1C([H])=C2C(C(C(=O)O[H])=C([H])N3C2=C(C=1N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])OC([H])([H])[C@]3([H])C([H])([H])[H])=O
Synonyms	Levofloxacin mesylate
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

References

[1]. DNA gyrase, topoisomerase IV, and the 4-quinolones. Microbiol Mol Biol Rev. 1997 Sep;61(3):377-92. [2]. A review of compounds exhibiting anti-orthopoxvirus activity in animal models. Antiviral Res. 2003 Jan;57(1-2):41-52. [3]. Effect of levofloxacin on some body tissues in mice. Effect of levofloxacin on some body tissues in mice. Iraqi Journal of Veterinary Sciences, 2021. [4]. In vitro and in vivo activities of levofloxacin against Mycobacterium tuberculosis. Antimicrob Agents Chemother. 1995 Jun;39(6):1341-4.

Solubility Data

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	2.1859 mL	10.9297 mL	21.8594 mL
	5 mM	0.4372 mL	2.1859 mL	4.3719 mL
	10 mM	0.2186 mL	1.0930 mL	2.1859 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.