LY83583 (LY 83583; LY-83583) is a novel and potent inhibitor of multple target proteins such as Msp1 and guanylate cyclase, also acts as a cGMP modulator that inhibits cGMP production.
Physicochemical Properties
| Molecular Formula | C15H10N2O2 |
| Molecular Weight | 250.25 |
| Exact Mass | 250.074 |
| Elemental Analysis | C, 71.99; H, 4.03; N, 11.19; O, 12.79 |
| CAS # | 91300-60-6 |
| PubChem CID | 3976 |
| Appearance | Brown to red solid powder |
| Density | 1.4±0.1 g/cm3 |
| Boiling Point | 446.9±45.0 °C at 760 mmHg |
| Melting Point | 184-185°C |
| Flash Point | 224.1±28.7 °C |
| Vapour Pressure | 0.0±1.1 mmHg at 25°C |
| Index of Refraction | 1.715 |
| LogP | 1.56 |
| Hydrogen Bond Donor Count | 1 |
| Hydrogen Bond Acceptor Count | 4 |
| Rotatable Bond Count | 2 |
| Heavy Atom Count | 19 |
| Complexity | 410 |
| Defined Atom Stereocenter Count | 0 |
| SMILES | O=C1C2C(=CC=CN=2)C(=O)C(NC2C=CC=CC=2)=C1 |
| InChi Key | GXIJYWUWLNHKNW-UHFFFAOYSA-N |
| InChi Code | InChI=1S/C15H10N2O2/c18-13-9-12(17-10-5-2-1-3-6-10)15(19)11-7-4-8-16-14(11)13/h1-9,17H |
| Chemical Name | 6-anilinoquinoline-5,8-dione |
| Synonyms | LY 83583; LY-83583; LY83583 |
| HS Tariff Code | 2934.99.9001 |
| Storage |
Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment (e.g. under nitrogen), avoid exposure to moisture and light. |
| Shipping Condition | Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs) |
Biological Activity
| References |
[1]. LY 83583 (6-anilino-5,8-quinolinedione) blocks nitrovasodilator-induced cyclic GMP increases and inhibition of platelet activation. Naunyn Schmiedebergs Arch Pharmacol. 1989 Jul;340(1):119-25. |
| Additional Infomation | 6-anilino-5,8-quinolinedione is a quinolone that is quinoline-5,8-dione in which the hydrogen at position 6 is replaced by an anilino group. It has a role as an antineoplastic agent and an EC 4.6.1.2 (guanylate cyclase) inhibitor. It is a quinolone, an aminoquinoline, an aromatic amine and a member of p-quinones. |
Solubility Data
| Solubility (In Vitro) | DMSO: ~200 mg/mL (~799.2 mM) |
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (9.99 mM) (saturation unknown) in 10% DMSO + 40% PEG300 +5% Tween-80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 + to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.9960 mL | 19.9800 mL | 39.9600 mL | |
| 5 mM | 0.7992 mL | 3.9960 mL | 7.9920 mL | |
| 10 mM | 0.3996 mL | 1.9980 mL | 3.9960 mL |