LW1564 is a HIF-1α inhibitor with an IC50 of 1.2 µM in HepG2. LW1564 inhibits mitochondrial respiration, reduces ATP production, and stimulates HIF-1α degradation, thereby inhibiting the proliferation of various cancer cells with a GI50 of 0.4-4.6 μM. LW1564 activates the AMPK signaling pathway and inhibits lipid synthesis. LW1564 exhibits antitumor activity in a HepG2 xenograft mouse model.

Physicochemical Properties

Molecular Formula	C42H48F3N3O5
Molecular Weight	731.84
CAS #	2668337-39-9
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

References

[1]. The disubstituted adamantyl derivative LW1564 inhibits the growth of cancer cells by targeting mitochondrial respiration and reducing hypoxia-inducible factor (HIF)-1α accumulation. Exp Mol Med. 2020 Nov;52(11):1845-1856.

Solubility Data

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	1.3664 mL	6.8321 mL	13.6642 mL
	5 mM	0.2733 mL	1.3664 mL	2.7328 mL
	10 mM	0.1366 mL	0.6832 mL	1.3664 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.