LUF5771 is a potent allosteric inhibitor of recombinant luteinizing hormone (recLH) and Org 43553. LUF5771 can partially activate LH receptors and has low efficacy.

Physicochemical Properties

Molecular Formula	C24H23NO2
Molecular Weight	357.44492650032
Exact Mass	357.172
CAS #	1141802-49-4
PubChem CID	44572264
Appearance	Typically exists as solid at room temperature
LogP	6
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	2
Rotatable Bond Count	5
Heavy Atom Count	27
Complexity	435
Defined Atom Stereocenter Count	0
InChi Key	YNYOWRRXJIPCGX-UHFFFAOYSA-N
InChi Code	InChI=1S/C24H23NO2/c26-24(25-22-13-7-8-14-22)27-23-16-20(18-9-3-1-4-10-18)15-21(17-23)19-11-5-2-6-12-19/h1-6,9-12,15-17,22H,7-8,13-14H2,(H,25,26)
Chemical Name	(3,5-diphenylphenyl) N-cyclopentylcarbamate
HS Tariff Code	2934.99.9001
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

Targets	recLH and Org 43553[1]
ln Vitro	Concentration-dependent allosteric inhibition is observed with LUF5771 (1 µM or 10 µM). LUF5771 causes radioligand dissociation to rise noticeably. Like Org 43553, LUF5771 most likely binds to the seven transmembrane domain. The LH receptor can be partially activated by 31 ±4% with just 10 µM of LUF5771[1].
References	[1]. Laura H. Heitman, et al. Substituted Terphenyl Compounds as the First Class of Low Molecular Weight Allosteric Inhibitors of the Luteinizing Hormone Receptor. Journal of Medicinal Chemistry 2009 52 (7), 2036-2042

Solubility Data

Solubility (In Vitro)

DMSO: 100 mg/mL (279.77 mM）

Solubility (In Vivo)

Solubility in Formulation 1: ≥ 2.5 mg/mL (6.99 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly.  (Please use freshly prepared in vivo formulations for optimal results.)

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	2.7977 mL	13.9884 mL	27.9767 mL
	5 mM	0.5595 mL	2.7977 mL	5.5953 mL
	10 mM	0.2798 mL	1.3988 mL	2.7977 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.