LE01 is part of an antibody-drug conjugate for ADC. LE01 contains an ADC linker and a DNA topoisomerase I inhibitor DXd. LE01 can be used to synthesize HER2-antibody-drug conjugate HER2-LE01.

Physicochemical Properties

Molecular Formula	C55H61FN10O14
Molecular Weight	1105.13
CAS #	2718125-83-6
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

Targets	Topoisomerase I Camptothecins
References	[1]. Evaluation of Double Self-Immolative Linker-Based Antibody-Drug Conjugate FDA022-BB05 with Enhanced Therapeutic Potential. J Med Chem. 2024 Nov 14;67(21):19852-19873.

Solubility Data

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	0.9049 mL	4.5244 mL	9.0487 mL
	5 mM	0.1810 mL	0.9049 mL	1.8097 mL
	10 mM	0.0905 mL	0.4524 mL	0.9049 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.