L-Threonine is a natural amino acid (AA) generated by microbial fermentation and may be utilized in food, medicine and feed.

Physicochemical Properties

Molecular Formula	C4H9NO3
Molecular Weight	119.1192
Exact Mass	119.058
CAS #	72-19-5
Appearance	White to off-white solid powder
Density	1.3±0.1 g/cm3
Boiling Point	345.8±32.0 °C at 760 mmHg
Melting Point	255ºC
Flash Point	162.9±25.1 °C
Vapour Pressure	0.0±1.7 mmHg at 25°C
Index of Refraction	1.507
LogP	-1.23
SMILES	O([H])[C@]([H])(C([H])([H])[H])[C@@]([H])(C(=O)O[H])N([H])[H]
InChi Key	AYFVYJQAPQTCCC-GBXIJSLDSA-N
InChi Code	InChI=1S/C4H9NO3/c1-2(6)3(5)4(7)8/h2-3,6H,5H2,1H3,(H,7,8)/t2-,3+/m1/s1
Chemical Name	(2S,3R)-2-amino-3-hydroxybutanoic acid
HS Tariff Code	2934.99.9001
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

References

[1]. Increasing L-threonine production in Escherichia coli by engineering the glyoxylate shunt and the L-threonine biosynthesis pathway. Appl Microbiol Biotechnol. 2018 Jul;102(13):5505-5518.

Solubility Data

Solubility (In Vitro)	H2O : ~33.33 mg/mL (~279.80 mM) DMSO :< 1 mg/mL
Solubility (In Vivo)	Solubility in Formulation 1: 50 mg/mL (419.74 mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with sonication.  (Please use freshly prepared in vivo formulations for optimal results.)

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	8.3949 mL	41.9745 mL	83.9490 mL
	5 mM	1.6790 mL	8.3949 mL	16.7898 mL
	10 mM	0.8395 mL	4.1974 mL	8.3949 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.