L-Serine-d3 is the deuterium labelled form of L-Serine. L-Serine ((-)-Serine; (S)-Serine) is one of the non-essential amino acid (AA)s that plays an important role in cell proliferation/growth.

Physicochemical Properties

Molecular Formula	C3H4D3NO3
Molecular Weight	108.11
Exact Mass	108.061
CAS #	105591-10-4
Related CAS #	L-Serine;56-45-1
PubChem CID	54089883
Appearance	White to off-white solid powder
Density	1.4±0.1 g/cm3
Boiling Point	394.8±32.0 °C at 760 mmHg
Flash Point	192.6±25.1 °C
Vapour Pressure	0.0±2.1 mmHg at 25°C
Index of Refraction	1.519
LogP	-1.58
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	2
Heavy Atom Count	7
Complexity	72.6
Defined Atom Stereocenter Count	1
SMILES	[2H][C@@](C(=O)O)(C([2H])([2H])O)N
InChi Key	MTCFGRXMJLQNBG-RBXBQAPRSA-N
InChi Code	InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m0/s1/i1D2,2D
Chemical Name	(2S)-2-amino-2,3,3-trideuterio-3-hydroxypropanoic acid
HS Tariff Code	2934.99.9001
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

ln Vitro	Drug compounds have included stable heavy isotopes of carbon, hydrogen, and other elements, mostly as quantitative tracers while the drugs were being developed. Because deuteration may have an effect on a drug's pharmacokinetics and metabolic properties, it is a cause for concern [1].
References	[1]. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

Solubility Data

Solubility (In Vitro)	H2O: 125 mg/mL (1156.23 mM)
Solubility (In Vivo)	Solubility in Formulation 1: 50 mg/mL (462.49 mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with sonication.  (Please use freshly prepared in vivo formulations for optimal results.)

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	9.2498 mL	46.2492 mL	92.4984 mL
	5 mM	1.8500 mL	9.2498 mL	18.4997 mL
	10 mM	0.9250 mL	4.6249 mL	9.2498 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.