L-Perillaldehyde is the major component in perilla essential oil. Inhalation of L-Perillaldehyde displays antidepressant-like activity via olfactory nerve function.

Physicochemical Properties

Molecular Formula	C10H14O
Molecular Weight	150.22
Exact Mass	150.104
CAS #	18031-40-8
PubChem CID	2724159
Appearance	Colorless to light yellow liquid
Density	1.0±0.1 g/cm3
Boiling Point	238.0±29.0 °C at 760 mmHg
Flash Point	95.6±0.0 °C
Vapour Pressure	0.0±0.5 mmHg at 25°C
Index of Refraction	1.543
LogP	2.68
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	1
Rotatable Bond Count	2
Heavy Atom Count	11
Complexity	201
Defined Atom Stereocenter Count	1
SMILES	O=C([H])C1=C([H])C([H])([H])[C@@]([H])(C(=C([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H]
InChi Key	RUMOYJJNUMEFDD-SNVBAGLBSA-N
InChi Code	InChI=1S/C10H14O/c1-8(2)10-5-3-9(7-11)4-6-10/h3,7,10H,1,4-6H2,2H3/t10-/m1/s1
Chemical Name	(4S)-4-prop-1-en-2-ylcyclohexene-1-carbaldehyde
Synonyms	(S)-(-)-Perillaldehyde (S)-PerillaldehydeLPerillaldehyde()PerillaldehydePerillaldehyde)
HS Tariff Code	2934.99.9001
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment (e.g. under nitrogen), avoid exposure to moisture.
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

ln Vivo	In pre-depressive model mice, L-Perillaldehyde (0.0965 and 0.965 mg/animal/day, 9 times, inhalation) can lessen the paralysis reaction during swimming [1].
Animal Protocol	Animal/Disease Models: Stress-induced depression-like model mouse [1]. 1] Doses: 0.0965 and 0.965 mg/mouse/day Route of Administration: Inhalation Experimental Results: diminished immobility in the forced swim test.
References	[1]. Antidepressant-like Effect of l-perillaldehyde in Stress-induced Depression-like Model Mice through Regulation of the Olfactory Nervous System. Evid Based Complement Alternat Med. 2011;2011:512697.
Additional Infomation	(-)-Perillaldehyde has been reported in Perilla frutescens, Perilla frutescens var. crispa, and other organisms with data available. See also: Paeonia lactiflora root (part of).

Solubility Data

Solubility (In Vitro)

DMSO : ~100 mg/mL (~665.69 mM)

Solubility (In Vivo)

Solubility in Formulation 1: ≥ 2.5 mg/mL (16.64 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: 2.5 mg/mL (16.64 mM) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), suspension solution; with ultrasonication. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. Solubility in Formulation 3: ≥ 2.5 mg/mL (16.64 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly.  (Please use freshly prepared in vivo formulations for optimal results.)

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	6.6569 mL	33.2845 mL	66.5690 mL
	5 mM	1.3314 mL	6.6569 mL	13.3138 mL
	10 mM	0.6657 mL	3.3285 mL	6.6569 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.