L-Isoleucine-1-13C is L-Isoleucine labeled with 13C. L-Isoleucine is a non-polar hydrophobic amino acid (AA). L-Isoleucine is an essential amino acid (AA).

Physicochemical Properties

Molecular Formula	C6H13NO2
Molecular Weight	131.17
Exact Mass	132.097
CAS #	81202-01-9
Related CAS #	L-Isoleucine;73-32-5
PubChem CID	13000968
Appearance	White to off-white solid powder
LogP	-1.7
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	3
Rotatable Bond Count	3
Heavy Atom Count	9
Complexity	103
Defined Atom Stereocenter Count	2
SMILES	C(O)(=O)[C@H]([C@@H](C)CC)N
InChi Key	AGPKZVBTJJNPAG-XDXFPRKMSA-N
InChi Code	InChI=1S/C6H13NO2/c1-3-4(2)5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t4-,5-/m0/s1/i6+1
Chemical Name	(2S,3S)-2-amino-3-methyl(113C)pentanoic acid
HS Tariff Code	2934.99.9001
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

ln Vitro	Drug compounds have included stable heavy isotopes of carbon, hydrogen, and other elements, mostly as quantitative tracers while the drugs were being developed. Because deuteration may have an effect on a drug's pharmacokinetics and metabolic properties, it is a cause for concern [1].
References	[1]. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

Solubility Data

Solubility (In Vitro)	H2O: 12.5 mg/mL (94.58 mM)
Solubility (In Vivo)	Solubility in Formulation 1: 25 mg/mL (189.15 mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with sonication.  (Please use freshly prepared in vivo formulations for optimal results.)

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	7.6237 mL	38.1185 mL	76.2369 mL
	5 mM	1.5247 mL	7.6237 mL	15.2474 mL
	10 mM	0.7624 mL	3.8118 mL	7.6237 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.