L-Glutamine-15N-1 is L-Glutamine labeled with 15N. L-Glutamine (L-Glutamic acid 5-amide) is a non-essential amino acid (AA) found in large amounts in the human body and involved in many metabolic processes. L-Glutamine provides a carbon source for oxidation in some cells.

Physicochemical Properties

Molecular Formula	C5H10N15NO3
Molecular Weight	147.14
Exact Mass	146.069
CAS #	59681-32-2
Related CAS #	L-Glutamine;56-85-9
PubChem CID	15560190
Appearance	White to off-white solid powder
Density	1.3±0.1 g/cm3
Boiling Point	445.6±40.0 °C at 760 mmHg
Melting Point	185ºC (dec.)(lit.)
Flash Point	223.3±27.3 °C
Vapour Pressure	0.0±2.3 mmHg at 25°C
Index of Refraction	1.524
LogP	-1.67
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	4
Heavy Atom Count	10
Complexity	146
Defined Atom Stereocenter Count	1
SMILES	C(CC(=O)[15NH2])[C@@H](C(=O)O)N
InChi Key	ZDXPYRJPNDTMRX-QQKKVIQDSA-N
InChi Code	InChI=1S/C5H10N2O3/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H2,7,8)(H,9,10)/t3-/m0/s1/i7+1
Chemical Name	(2S)-2-amino-5-(15N)azanyl-5-oxopentanoic acid
HS Tariff Code	2934.99.9001
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

ln Vitro	Drug compounds have been modified to include stable heavy isotopes of hydrogen, carbon, and other elements. These isotopes are mostly utilized as quantitative tracers during the drug development process. 1].
References	[1]. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

Solubility Data

Solubility (In Vitro)	H2O : 25 mg/mL (169.91 mM)
Solubility (In Vivo)	Solubility in Formulation 1: 12.5 mg/mL (84.95 mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with sonication.  (Please use freshly prepared in vivo formulations for optimal results.)

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	6.7962 mL	33.9812 mL	67.9625 mL
	5 mM	1.3592 mL	6.7962 mL	13.5925 mL
	10 mM	0.6796 mL	3.3981 mL	6.7962 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.