L-Glutamic acid-d5 is the deuterated form of L-Glutamic acid. L-Glutamic acid is an excitatory amino acid (AA) neurotransmitter and an agonist of all subtypes of glutamate receptors (metabotropic kainate, NMDA and AMPA). It has an agonistic effect on the release of DA from dopaminergic nerve terminals.

Physicochemical Properties

Molecular Formula	C5H4D5NO4
Molecular Weight	152.16
Exact Mass	152.084
CAS #	2784-50-1
Related CAS #	L-Glutamic acid;56-86-0
PubChem CID	12248503
Appearance	White to off-white solid powder
Density	1.4±0.1 g/cm3
Boiling Point	333.8±32.0 °C at 760 mmHg
Melting Point	205ºC (dec.)(lit.)
Flash Point	155.7±25.1 °C
Vapour Pressure	0.0±1.5 mmHg at 25°C
Index of Refraction	1.522
LogP	-1.43
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	4
Heavy Atom Count	10
Complexity	145
Defined Atom Stereocenter Count	1
SMILES	[2H][C@@](C(=O)O)(C([2H])([2H])C([2H])([2H])C(=O)O)N
InChi Key	WHUUTDBJXJRKMK-NKXUJHECSA-N
InChi Code	InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m0/s1/i1D2,2D2,3D
Chemical Name	(2S)-2-amino-2,3,3,4,4-pentadeuteriopentanedioic acid
HS Tariff Code	2934.99.9001
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

ln Vitro	Drug compounds have included stable heavy isotopes of carbon, hydrogen, and other elements, mostly as quantitative tracers while the drugs were being developed. Because deuteration may have an effect on a drug's pharmacokinetics and metabolic properties, it is a cause for concern [1].
References	[1]. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.
Additional Infomation	L-glutamic acid-d5 is a L-glutamic acid and a deuterated compound.

Solubility Data

Solubility (In Vitro)	H2O : 14.29 mg/mL (93.91 mM)
Solubility (In Vivo)	Solubility in Formulation 1: 7.14 mg/mL (46.92 mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with sonication (<60°C).  (Please use freshly prepared in vivo formulations for optimal results.)

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	6.5720 mL	32.8601 mL	65.7203 mL
	5 mM	1.3144 mL	6.5720 mL	13.1441 mL
	10 mM	0.6572 mL	3.2860 mL	6.5720 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.