L-Carnitine-d3 (HCl) is the deuterium labelled form of L-Carnitine HCl.

Physicochemical Properties

Molecular Formula	C7H13D3CLNO3
Molecular Weight	200.68
Exact Mass	186.085
CAS #	350818-62-1
Related CAS #	(±)-Carnitine chloride;461-05-2
PubChem CID	71309656
Appearance	Off-white to light yellow solid powder
Melting Point	131-135°C
LogP	0.185
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	4
Heavy Atom Count	12
Complexity	139
Defined Atom Stereocenter Count	1
SMILES	[2H]C([2H])([2H])[N+](C)(C)C[C@@H](CC(=O)O)O.[Cl-]
InChi Key	JXXCENBLGFBQJM-QKBJTWEASA-N
InChi Code	InChI=1S/C7H15NO3.ClH/c1-8(2,3)5-6(9)4-7(10)11;/h6,9H,4-5H2,1-3H3;1H/t6-;/m1./s1/i1D3;
Chemical Name	[(2R)-3-carboxy-2-hydroxypropyl]-dimethyl-(trideuteriomethyl)azanium;chloride
HS Tariff Code	2934.99.9001
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment, avoid exposure to moisture.
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

ln Vitro	Drug compounds have included stable heavy isotopes of carbon, hydrogen, and other elements, mostly as quantitative tracers while the drugs were being developed. Because deuteration may have an effect on a drug's pharmacokinetics and metabolic properties, it is a cause for concern [1].
References	[1]. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

Solubility Data

Solubility (In Vitro)	H2O: 250 mg/mL (1245.76 mM)
Solubility (In Vivo)	Solubility in Formulation 1: 100 mg/mL (498.31 mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with sonication.  (Please use freshly prepared in vivo formulations for optimal results.)

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	4.9831 mL	24.9153 mL	49.8306 mL
	5 mM	0.9966 mL	4.9831 mL	9.9661 mL
	10 mM	0.4983 mL	2.4915 mL	4.9831 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.