Koenine is a carbazole alkaloid. It is predicted that Koenine has strong binding affinity and inhibitory ability to SARS-CoV-2 main protease (Mpro), and can be used in the research of anti-new coronavirus drugs.

Physicochemical Properties

Molecular Formula	C18H17NO2
Molecular Weight	279.33
CAS #	28200-63-7
SMILES	O1C2C(C)=CC3C4C=C(C=CC=4NC=3C=2C=CC1(C)C)O
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

References

[1]. Antidiarrhoeal activity of carbazole alkaloids from Murraya koenigii Spreng (Rutaceae) seeds. Fitoterapia. 2010 Jan;81(1):72-4. [2]. A Computational Study of Carbazole Alkaloids from Murraya koenigii as Potential SARS-CoV-2 Main Protease Inhibitors. Appl Biochem Biotechnol. 2023 Jan;195(1):573-596.

Solubility Data

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	3.5800 mL	17.9000 mL	35.7999 mL
	5 mM	0.7160 mL	3.5800 mL	7.1600 mL
	10 mM	0.3580 mL	1.7900 mL	3.5800 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.