KKI-5 (TFA) is a specific inhibitor of tissue kallikrein. KKI-5 (TFA) reduces breast cancer/tumor cell infiltration.

Physicochemical Properties

Molecular Formula	C37H56F3N11O11
Molecular Weight	887.90
Related CAS #	KKI-5;97145-43-2
Appearance	White to off-white solid powder
HS Tariff Code	2934.99.9001
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment, avoid exposure to moisture.
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

Targets	Kallikrein[1]
ln Vitro	The aa386-391 of bovine kininogen-1, which includes the aa388-389 kallikrein proteolytic site, is equivalent to the KKI-5 Peptide. Since the synthetic KKI-5 can reduce the invasion of breast cancer cells, its function in cancer cell invasion and metastasis is being studied[1].
References	[1]. Mapping the binding site of tissue kallikrein: preparation and testing of all possible substrate analog inhibitors homologous with the sequence of kininogen between Ser386 and Gln392. J Med Chem. 1992 Aug 21;35(17):3094-102.

Solubility Data

Solubility (In Vitro)	H2O :~9.09 mg/mL (~10.24 mM)
Solubility (In Vivo)	Solubility in Formulation 1: 12.5 mg/mL (14.08 mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with sonication.  (Please use freshly prepared in vivo formulations for optimal results.)

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	1.1263 mL	5.6313 mL	11.2625 mL
	5 mM	0.2253 mL	1.1263 mL	2.2525 mL
	10 mM	0.1126 mL	0.5631 mL	1.1263 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.