KCNQ1 activator-1 (compound 3) is a potent KCNQ1 channel activator. KCNQ1 activator-1 may be used for studying long QT syndrome (LQTS).

Physicochemical Properties

Molecular Formula	C22H23N3O4S2
Molecular Weight	457.57
Exact Mass	457.112
CAS #	1008671-38-2
PubChem CID	4880560
Appearance	Typically exists as solid at room temperature
Flash Point	312.4±37.0 °C(Predicted)
LogP	3.9
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	7
Rotatable Bond Count	6
Heavy Atom Count	31
Complexity	700
Defined Atom Stereocenter Count	0
SMILES	N1(S(C2=CC=CC=C2)(=O)=O)CCCCC1C(NC1=NC(C2=CC=C(OC)C=C2)=CS1)=O
InChi Key	UUTYPVHYRISWDI-UHFFFAOYSA-N
InChi Code	InChI=1S/C22H23N3O4S2/c1-29-17-12-10-16(11-13-17)19-15-30-22(23-19)24-21(26)20-9-5-6-14-25(20)31(27,28)18-7-3-2-4-8-18/h2-4,7-8,10-13,15,20H,5-6,9,14H2,1H3,(H,23,24,26)
Chemical Name	1-(benzenesulfonyl)-N-[4-(4-methoxyphenyl)-1,3-thiazol-2-yl]piperidine-2-carboxamide
HS Tariff Code	2934.99.9001
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

Solubility Data

Solubility (In Vitro)

DMSO : ~250 mg/mL (~546.36 mM)

Solubility (In Vivo)

Solubility in Formulation 1: ≥ 2.08 mg/mL (4.55 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.8 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly.  (Please use freshly prepared in vivo formulations for optimal results.)

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	2.1855 mL	10.9273 mL	21.8546 mL
	5 mM	0.4371 mL	2.1855 mL	4.3709 mL
	10 mM	0.2185 mL	1.0927 mL	2.1855 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.