Jun13728 is a potent and covalent SARS-CoV-2 papain-like protease inhibitor with IC50 of 0.1 μM. Jun13728 can be used for SARS-CoV-2 antiviral studies.

Physicochemical Properties

Molecular Formula	C34H36F2N8O4
Molecular Weight	658.70
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

References

[1]. Structure-Based Design of Covalent SARS-CoV-2 Papain-like Protease Inhibitors. J Med Chem. 2024 Nov 28;67(22):20399-20420.

Solubility Data

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	1.5181 mL	7.5907 mL	15.1814 mL
	5 mM	0.3036 mL	1.5181 mL	3.0363 mL
	10 mM	0.1518 mL	0.7591 mL	1.5181 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.