JW480 is a potent and specific inhibitor of serine hydrolase KIAA1363.

Physicochemical Properties

Molecular Formula	C22H23NO2
Molecular Weight	333.42
Exact Mass	333.172
CAS #	1354359-53-7
PubChem CID	57330099
Appearance	White to off-white solid powder
Density	1.1±0.1 g/cm3
Boiling Point	486.2±38.0 °C at 760 mmHg
Flash Point	247.9±26.8 °C
Vapour Pressure	0.0±1.2 mmHg at 25°C
Index of Refraction	1.605
LogP	5.93
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	2
Rotatable Bond Count	6
Heavy Atom Count	25
Complexity	422
Defined Atom Stereocenter Count	0
SMILES	CC(C1=CC=CC=C1OC(NCCC2=CC3=CC=CC=C3C=C2)=O)C
InChi Key	PCNJGBMWAZRVEA-UHFFFAOYSA-N
InChi Code	InChI=1S/C22H23NO2/c1-16(2)20-9-5-6-10-21(20)25-22(24)23-14-13-17-11-12-18-7-3-4-8-19(18)15-17/h3-12,15-16H,13-14H2,1-2H3,(H,23,24)
Chemical Name	(2-propan-2-ylphenyl) N-(2-naphthalen-2-ylethyl)carbamate
HS Tariff Code	2934.99.9001
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: This product requires protection from light (avoid light exposure) during transportation and storage.
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

Additional Infomation

Carbamic acid, N-[2-(2-naphthalenyl)ethyl]-, 2-(1-methylethyl)phenyl ester is a member of naphthalenes.

Solubility Data

Solubility (In Vitro)

DMSO : ~100 mg/mL (~299.92 mM)

Solubility (In Vivo)

Solubility in Formulation 1: 2.5 mg/mL (7.50 mM) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), suspension solution; with sonication. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (7.50 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly.  (Please use freshly prepared in vivo formulations for optimal results.)

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	2.9992 mL	14.9961 mL	29.9922 mL
	5 mM	0.5998 mL	2.9992 mL	5.9984 mL
	10 mM	0.2999 mL	1.4996 mL	2.9992 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.