JAK-IN-39 (compound 11) is a JAK inhibitor with IC50 of 0.05, 1.18, and 0.03 nM for JAK1, JAK2, and JAK3. JAK-IN-39 can inhibit the cell viability of TF-1 cells and inhibit the production of TNFα and INFγ in lymphocytes in vitro.

Physicochemical Properties

Molecular Formula	C25H26N10O2
Molecular Weight	498.54
CAS #	2250013-34-2
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

Targets	JAK1 0.05 nM (IC50); JAK2 1.18 nM (IC50); JAK3 0.03 nM (IC50)
References	[1]. Pyrazole1,5-apyrimidine derivatives as kinase jak inhibitors.WO. WO2018206739A1. 2018-05-10.

Solubility Data

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	2.0059 mL	10.0293 mL	20.0586 mL
	5 mM	0.4012 mL	2.0059 mL	4.0117 mL
	10 mM	0.2006 mL	1.0029 mL	2.0059 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.