Ifebemtinib (BI-853520) hydrochloride is an orally active, potent inhibitor of focal adhesion kinase (FAK) (recombinant FAK IC50=1 nM). Ifebemtinib hydrochloride exhibits antiproliferative activity against cancer cells.

Physicochemical Properties

Molecular Formula	C28H29CLF4N6O4
Molecular Weight	625.01
Related CAS #	Ifebemtinib;1227948-82-4
Synonyms	BI-853520 hydrochloride; IN-10018 hydrochloride
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

References

[1]. Efficacy of the highly selective focal adhesion kinase inhibitor BI 853520 in adenocarcinoma xenograft models is linked to a mesenchymal tumor phenotype. Oncogenesis. 2018 Feb 23;7(2):21. [2]. The FAK inhibitor BI 853520 exerts anti-tumor effects in breast cancer. Oncogenesis. 2018 Sep 20;7(9):73. [3]. Efficacy of the highly selective focal adhesion kinase inhibitor BI 853520 in adenocarcinoma xenograft models is linked to a mesenchymal tumor phenotype. Oncogenesis. 2018 Feb 23;7(2):21.

Solubility Data

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	1.6000 mL	7.9999 mL	15.9997 mL
	5 mM	0.3200 mL	1.6000 mL	3.1999 mL
	10 mM	0.1600 mL	0.8000 mL	1.6000 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.