Ibetazol is an inhibitor of importin β1 (or KPNB1), which binds to Cys585 of importin β1, thereby inhibiting importin β1-mediated nuclear import with EC50 of 6.1 µM.

Physicochemical Properties

Molecular Formula	C13H11F3N2OS
Molecular Weight	300.30
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

References

[1]. Ibetazol, a novel inhibitor of importin β1-mediated nuclear import. Commun Biol. 2024 Nov 23;7(1):1560.

Solubility Data

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	3.3300 mL	16.6500 mL	33.3000 mL
	5 mM	0.6660 mL	3.3300 mL	6.6600 mL
	10 mM	0.3330 mL	1.6650 mL	3.3300 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.